HEMATOPOIESIS AND STEM CELLS Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2

1Molecular Genetics of Stem Cells Laboratory, Institute of Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC; 2Immune Signalling Laboratory, Cancer Immunology, Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia; 3Department of Clinical Hematology, Peter MacCallum Cancer Centre, East Melbourne, Australia; 4Hematology and Oncology and Division of Viral and Immune Disorders and Cancers, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC; 5Mitotic Mechanisms and Chromosome Dynamics Laboratory, IRIC, University of Montreal, Montreal, QC; 6Centre for Micro-Photonics, Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Hawthorn, Australia; 7Department of Medical Biophysics and Immunology, The Ontario Cancer Institute, University of Toronto, Toronto, ON; and 8Division of Hematology and Leukemia Cell Bank of Quebec, Maisonneuve-Rosemont Hospital, Montreal, QC